Epithalon (also spelled Epitalon) is a synthetic tetrapeptide (Ala-Glu-Asp-Gly) based on the natural peptide epithalamin, which is produced by the pineal gland. It was developed by Russian scientist Professor Vladimir Khavinson and has been studied for over 35 years.
Epithalon is primarily known for its ability to activate telomerase, the enzyme responsible for maintaining telomere length. Telomere shortening is a key biomarker of cellular aging, and telomerase activation may slow or reverse aspects of this process.
Epithalon is not FDA-approved. Most research originates from Russian studies, with limited Western clinical trial data. It is available through compounding pharmacies for off-label use.
Animal studies show promising longevity effects; human data is limited but supportive.
Epithalon works primarily through the pineal gland and telomerase pathways:
Study demonstrating that epithalon activated telomerase in human somatic cells and induced telomere elongation.
Research showing increased lifespan and improved biomarkers of aging in animal models treated with epithalon.
Overview of pineal gland peptides including epithalamin and epithalon, reviewing their geroprotective and anti-aging properties.
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Disclaimer: The information on this page was generated with the assistance of artificial intelligence and compiled from publicly available sources. While efforts are made to ensure accuracy, information may be incomplete, outdated, or incorrect and should not be relied upon as medical advice.
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