P-Shot Benefits: PRP for ED | R2 Medical Clinic Denver

Medically Reviewed By: Dr. Erik Natkin, DO — Founder, R2 Medical Clinic

Key Takeaways

The P-Shot (Priapus Shot) uses platelet-rich plasma (PRP) drawn from your own blood to stimulate tissue regeneration, improve blood flow, and enhance sensitivity in penile tissue.
The procedure takes 30 to 45 minutes at R2 Medical Clinic in Denver, involves topical numbing for comfort, and requires zero downtime.
Benefits include improved erectile firmness, increased sensation, enhanced size potential, and natural healing without synthetic drugs or implants.
Results develop progressively over several weeks as new blood vessels form and tissue regeneration occurs, with full effects typically visible by 3 months.
The P-Shot can be combined with InMode ApexRF, testosterone replacement therapy, and other modalities for a comprehensive approach to men's sexual health.

What Is the P-Shot (Priapus Shot)?

The P-Shot, formally known as the Priapus Shot, is a regenerative medicine procedure that harnesses the healing power of platelet-rich plasma to restore and enhance male sexual function. Named after the Greek god of fertility, this treatment uses growth factors concentrated from your own blood to stimulate genuine tissue repair in penile tissue.

At R2 Medical Clinic in Denver, Dr. Erik Natkin, DO, performs the P-Shot as part of a comprehensive men's health program. With training in orthopedic surgery, pain management, and regenerative medicine, Dr. Natkin understands tissue regeneration at a level that most practitioners simply do not. PRP therapy is not new to his practice. The same platelet-rich plasma technology used in the P-Shot has been used for years in orthopedic medicine to accelerate healing in tendons, ligaments, and joints. Dr. Natkin applies that same regenerative science to men's intimate wellness.

The fundamental principle is straightforward: your blood contains platelets loaded with growth factors that trigger tissue repair. When these platelets are concentrated and delivered directly to penile tissue, they activate a cascade of regeneration including new blood vessel formation, collagen synthesis, and nerve tissue repair.

How the P-Shot Works: The Science of PRP

Understanding the P-Shot requires understanding platelet-rich plasma and what it does at the cellular level.

What Is PRP?

Platelet-rich plasma is a concentrated preparation of your own blood platelets suspended in plasma. Normal blood contains approximately 150,000 to 400,000 platelets per microliter. PRP concentrates that number to 3 to 5 times above baseline, delivering a dense payload of growth factors directly to the target tissue.

The key growth factors in PRP include:

Platelet-Derived Growth Factor (PDGF) stimulates cell proliferation and new blood vessel formation.
Vascular Endothelial Growth Factor (VEGF) is the primary driver of angiogenesis, the creation of new blood vessels from existing ones.
Transforming Growth Factor-Beta (TGF-B) promotes collagen production and tissue remodeling.
Epidermal Growth Factor (EGF) stimulates cell growth, proliferation, and differentiation.
Fibroblast Growth Factor (FGF) accelerates wound healing and tissue repair.

When these growth factors are injected into penile tissue, they initiate a sustained regenerative response that unfolds over weeks to months.

What Happens After Injection

The P-Shot triggers a multi-phase healing cascade:

Phase 1: Inflammatory Response (Days 1–7). The concentrated platelets activate and release their growth factors. This initiates a controlled inflammatory response that recruits stem cells and repair cells to the injection site.
Phase 2: Proliferation (Weeks 2–6). New collagen is synthesized. Angiogenesis begins, forming new capillaries and blood vessels throughout the treated tissue. Smooth muscle cells regenerate. Nerve endings begin repair.
Phase 3: Remodeling (Weeks 6–12+). Collagen matures and organizes. New blood vessels stabilize and become functional. Tissue gains improved structural integrity, vascularity, and sensitivity. This is when patients typically experience the full benefit of the treatment.

The P-Shot Procedure at R2 Medical Clinic

The entire P-Shot procedure takes 30 to 45 minutes at our Denver clinic. Here is exactly what to expect:

Step 1: Blood Collection

A small amount of blood is drawn from your arm, identical to a routine blood draw. The volume is typically 15 to 30 milliliters, roughly 1 to 2 tablespoons.

Step 2: PRP Preparation

Your blood is placed in a centrifuge, a medical-grade device that spins the sample at high speed to separate its components. Red blood cells, white blood cells, and platelet-poor plasma are separated from the platelet-rich layer. This concentrated PRP is then extracted and prepared for injection.

The entire centrifuge process takes approximately 10 to 15 minutes. R2 Medical Clinic uses advanced preparation protocols to ensure maximum platelet concentration and growth factor yield.

Step 3: Targeted Injection

Before injection, a topical numbing agent is applied to the treatment area. Most patients report that the numbing process eliminates virtually all discomfort. Dr. Natkin or Allison Wright, FNP-C, then uses a fine needle to deliver the PRP into specific areas of the penile tissue.

The injection targets zones that are critical for erectile function and sensitivity. Precise placement ensures that growth factors reach the tissue where they will have the greatest impact on blood flow, nerve function, and structural support.

After the Procedure

You can return to normal activities immediately. There is no surgical recovery, no stitches, and no activity restrictions beyond basic common-sense guidelines for the first 24 to 48 hours. Most patients resume sexual activity within 24 to 48 hours. Mild soreness or swelling at the injection site is normal and resolves quickly.

Benefits of the P-Shot

The P-Shot produces a range of measurable improvements in male sexual function and anatomy:

Improved Erectile Quality

The primary benefit for most men is stronger, more reliable erections. By promoting new blood vessel growth and improving tissue health, the P-Shot enhances the vascular mechanism that makes erections possible. Men who have experienced declining erectile firmness due to aging, cardiovascular factors, or other causes often see meaningful restoration.

Increased Sensitivity and Sensation

Nerve tissue repair is a direct outcome of PRP therapy. Many men experience decreased penile sensitivity over time, which reduces pleasure and can contribute to difficulty reaching orgasm. The P-Shot stimulates nerve regeneration that can restore sensation to levels many men thought were permanently diminished.

Enhanced Size Potential

Improved blood flow capacity and tissue regeneration can result in measurable gains in both length and girth. As new blood vessels form and tissue expands to accommodate greater blood volume, many patients observe visible enhancement. These changes are natural and proportional, not the result of synthetic fillers or implants.

Enhanced Sexual Performance

The combined effects of improved blood flow, stronger tissue, better sensitivity, and increased confidence translate into enhanced overall sexual performance. Many men report improvements in stamina, arousal response, and satisfaction for both themselves and their partners.

Natural and Biocompatible

Because PRP comes from your own blood, there is no risk of allergic reaction, rejection, or foreign body complications. The treatment works with your body's own healing mechanisms rather than introducing synthetic chemicals or materials.

Who Should Consider the P-Shot?

The P-Shot is appropriate for men across a wide spectrum of needs and goals:

Men with erectile dysfunction who want a drug-free alternative or complement to medications
Men noticing age-related decline in erectile firmness, sensitivity, or sexual performance
Men recovering from prostate surgery or treatment who have experienced changes in erectile function
Men with Peyronie's disease who have developed scar tissue causing curvature or discomfort
Men who want enhancement beyond their current baseline, even if they do not have diagnosed ED
Men who want to reduce or eliminate dependence on PDE5 inhibitor medications
Men seeking a natural approach that uses their own biology rather than synthetic drugs

During your consultation at R2 Medical Clinic, Dr. Natkin will evaluate your specific situation, discuss your goals, and recommend whether the P-Shot, alone or combined with other therapies, is the right approach.

P-Shot Results: What to Expect and When

Understanding the timeline of P-Shot results helps set accurate expectations:

Weeks 1–2

Some men notice early improvements in sensitivity and mild increases in blood flow. The initial inflammatory phase is active, recruiting healing cells to the treatment area.

Weeks 3–6

Noticeable improvements in erectile firmness and sensitivity become apparent. New blood vessel formation is actively underway. Many men report that morning erections return or become stronger during this period.

Weeks 6–12

Full results develop as collagen matures, blood vessels stabilize, and tissue remodeling completes. This is when size changes, if they occur, become most apparent. Erectile quality and sensitivity reach their peak improvement.

Beyond 12 Weeks

Results continue to consolidate. Many men experience sustained benefits for 12 to 18 months or longer from a single treatment. Some patients choose to have repeat treatments annually to maintain and build upon their results.

Combining the P-Shot with Other Treatments

At R2 Medical Clinic, the P-Shot is frequently integrated into broader treatment protocols:

P-Shot + InMode ApexRF

This combination is one of the most powerful approaches to ED treatment available. The P-Shot delivers concentrated growth factors directly into penile tissue while ApexRF uses radiofrequency energy to build new blood vessels and electrical muscle stimulation to strengthen the pelvic floor. Together, they address tissue quality, vascular function, and muscular support simultaneously.

P-Shot + Testosterone Replacement Therapy

Hormonal optimization through TRT establishes the systemic foundation for sexual health. When testosterone levels are restored to optimal ranges, the local tissue regeneration from the P-Shot becomes even more effective. Many men with low testosterone and ED benefit enormously from this combination.

P-Shot + Peptide Therapy

Certain peptide protocols can enhance growth hormone signaling, improve recovery, and support the regenerative processes initiated by PRP. Dr. Natkin can recommend specific peptide combinations that complement P-Shot therapy based on your individual health profile.

Why Provider Selection Matters for the P-Shot

The P-Shot is a procedure where provider expertise significantly impacts outcomes. At R2 Medical Clinic, Dr. Erik Natkin brings a regenerative medicine background that most P-Shot providers lack.

PRP preparation quality matters. Not all PRP systems produce the same concentration of platelets and growth factors. R2 Medical Clinic uses advanced preparation protocols that maximize therapeutic potency.

Injection technique matters. Precise placement of PRP into the correct tissue layers and zones determines how effectively the growth factors can work. Dr. Natkin's training in injection-based therapies across orthopedic and pain management applications translates directly to superior P-Shot technique.

Comprehensive evaluation matters. ED is rarely caused by a single factor. Dr. Natkin evaluates hormonal status, vascular health, neurological function, and overall wellness before recommending any treatment. This ensures the P-Shot is deployed as part of an intelligent strategy rather than an isolated intervention.

R2 Medical Clinic serves patients from Denver, Arvada, Wheatridge, Castle Rock, and the greater metro area from our primary location at 1873 S Bellaire St, Suite 1215, Denver, with additional locations in Arvada-Wheatridge and Castle Rock.

Frequently Asked Questions

Does the P-Shot actually work?

Yes. The P-Shot is based on platelet-rich plasma technology that has been used successfully in orthopedic medicine and wound healing for over two decades. When applied to penile tissue, PRP stimulates the same regenerative processes: new blood vessel formation, collagen production, and tissue repair. Results vary by individual, but the majority of men treated at R2 Medical Clinic report meaningful improvements in erectile function, sensitivity, and overall satisfaction.

How much does the P-Shot cost in Denver?

P-Shot pricing at R2 Medical Clinic depends on whether the treatment is performed as a standalone procedure or as part of a combination protocol. We provide transparent pricing during your consultation and offer flexible payment options. Call (720) 640-2333 for current pricing information.

Is the P-Shot painful?

The procedure involves a fine needle injection, but topical numbing is applied before any injection takes place. Most patients at R2 Medical Clinic describe the sensation as mild pressure rather than pain. The numbing process is effective and the actual injection takes only a few minutes. Discomfort is minimal and brief.

How many P-Shot treatments do I need?

Many men experience significant improvement from a single P-Shot treatment. Some patients choose to have 2 to 3 treatments spaced several weeks apart for maximum benefit, particularly if they are addressing moderate to severe ED. Dr. Natkin will recommend the optimal number of treatments based on your individual assessment.

How long do P-Shot results last?

Results from the P-Shot typically last 12 to 18 months, with some patients experiencing benefits for longer. Annual maintenance treatments can sustain and build upon results over time. Because the P-Shot promotes actual tissue regeneration rather than temporary symptom masking, the improvements are structurally real rather than pharmacologically dependent.

Can the P-Shot be combined with other ED treatments?

Absolutely. At R2 Medical Clinic, we frequently combine the P-Shot with InMode ApexRF (radiofrequency and EMS therapy), testosterone replacement therapy, and other modalities. Combination protocols often produce results that exceed what any single treatment can achieve. Dr. Natkin designs individualized multi-modal treatment plans based on each patient's specific needs and goals.

Why Choose R2 Medical Clinic for the P-Shot

R2 Medical Clinic provides the P-Shot within a comprehensive men's health framework that goes far beyond a single injection. Dr. Erik Natkin, DO, brings training in orthopedic surgery, pain management, and regenerative medicine to every patient encounter. This means your P-Shot is performed with expert technique, optimal PRP preparation, and precise anatomical knowledge.

Our clinic evaluates every patient holistically, considering hormonal health, vascular function, and lifestyle factors alongside your sexual health concerns. We do not offer one-size-fits-all solutions. Every treatment plan is built around your specific physiology and goals.

Ready to restore your sexual health naturally? Schedule your free consultation. Call (720) 640-2333 or visit r2medicalclinic.com.

Dr. Erik Natkin, DO — Founder, R2 Medical Clinic

Dr. Natkin is a Doctor of Osteopathic Medicine who completed orthopedic surgery training in Oregon before specializing in regenerative medicine, pain management, and hormone optimization. As the founder of R2 Medical Clinic, he has helped thousands of patients in the Denver area reclaim their vitality through evidence-based, personalized treatment. A Colorado resident since 1987 and avid cyclist, Dr. Natkin brings both clinical excellence and genuine passion for long-term wellness to every patient he serves.

Medical Disclaimer

This content is provided for informational purposes only and does not constitute medical advice, diagnosis, or treatment. Individual results may vary. The P-Shot is a medical procedure that should only be performed by qualified healthcare providers. Erectile dysfunction can be a symptom of underlying health conditions that require medical evaluation. Always consult with a qualified healthcare provider before beginning any treatment. The information presented here reflects the clinical experience of R2 Medical Clinic and is not intended to replace a professional medical consultation.