O-ShotPRP Therapy for Women in Denver
Sexual function can change with age, menopause, hormonal changes, medications, childbirth, medical conditions and other factors. For some women, platelet-rich plasma (PRP) may be considered as part of a broader approach to female sexual health.
At R2 Medical Clinic, the O-Shot uses platelet-rich plasma prepared from your own blood and injected into targeted areas of the vulvovaginal region. PRP has been studied for its potential effects on sexual function, sensation, arousal and other vulvovaginal symptoms.
Research into PRP for female sexual function is promising but still developing. Treatment recommendations should be individualized based on your symptoms, medical history and other potential contributors to sexual dysfunction.
O-Shot Treatment
What is the O-Shot?
The O-Shot is a non-surgical procedure that uses platelet-rich plasma derived from a small sample of your own blood.
Platelets contain growth factors and other biologically active proteins involved in normal tissue repair and healing. PRP concentrates these platelets and is used in multiple areas of medicine.
For female sexual health, PRP is injected into selected areas of the vulvovaginal region. Clinical studies have investigated whether these injections may improve certain aspects of female sexual function.
30-45
Minutes Procedure
0
Days Downtime
6-8
Weeks to Results
Why Women Consider PRP Therapy
Women may seek evaluation because of changes in:
- Sexual sensation
- Arousal
- Ability to achieve orgasm
- Vaginal lubrication
- Sexual satisfaction
- Vaginal or vulvar discomfort
- Sexual function associated with hormonal or menopausal changes
- ✓Enhanced sensitivity and arousal
- ✓Improved ability to achieve orgasm
- ✓Reduced urinary incontinence
- ✓Natural healing using your own blood platelets
- ✓Zero downtime — return to normal activities immediately
Female sexual dysfunction is complex, however, and PRP is not necessarily the appropriate treatment for every symptom.
Low desire, difficulty with arousal, orgasmic dysfunction and pain with intercourse can have different underlying causes. Hormonal changes, medications, genitourinary syndrome of menopause (GSM), pelvic floor disorders, psychological factors, relationship factors and other medical conditions may contribute.
For this reason, treatment at R2 Medical Clinic begins with an individualized evaluation rather than assuming PRP is appropriate for every woman experiencing sexual concerns.
How It Works
1. Blood Draw and PRP Preparation
A small amount of your blood is collected and processed in a centrifuge to separate and concentrate platelet-rich plasma.
2. Treatment Area Preparation
A topical anesthetic is applied to help minimize discomfort during the procedure.
3. Targeted PRP Injection
The prepared PRP is injected into selected areas based on the treatment protocol and your individual symptoms.
The entire appointment typically takes approximately 30–45 minutes, and most patients can return to normal daily activities shortly afterward.
What Does the Research Say About PRP for Female Sexual Function?
Research evaluating platelet-rich plasma for female sexual health is evolving.
A 2026 randomized, placebo-controlled trial published in Obstetrics & Gynecology evaluated vaginal PRP injections compared with saline placebo. Women receiving PRP demonstrated greater improvement in overall Female Sexual Function Index (FSFI) scores, and a greater percentage reported improvement in sexual function at six months.
The study also observed improvements within the PRP group in measures of desire, arousal, lubrication and orgasm, although differences in these individual domains were not statistically significant compared with placebo.
No serious adverse events were reported in the study.
A 2026 systematic review in The Journal of Sexual Medicine evaluated 18 studies involving vulvovaginal PRP. The review found that PRP was associated with improvements in symptoms, sexual function and vaginal health in several studies, with generally mild reported adverse effects.
However, researchers also identified important limitations, including small study populations, differences in PRP preparation and injection techniques, and variability in treatment protocols.
Additional high-quality randomized trials are needed to determine which patients are most likely to benefit, the optimal treatment protocol and the durability of treatment effects.
PRP injections for female sexual dysfunction remain an emerging treatment and are not considered established first-line therapy for female sexual dysfunction.
Potential Benefits of O-Shot Therapy
Enhanced Sexual Sensation
Increased sensitivity and pleasure.
Improved Natural Lubrication
Reduced dryness and discomfort.
Increased Arousal and Orgasm
Stronger, more frequent orgasms.
Reduced Pain During Intercourse
Improved tissue health and elasticity.
Improved Urinary Incontinence
Strengthened pelvic floor tissue.
Enhanced Sexual Satisfaction
Overall improvement in intimate wellness.
Non-Surgical
No incisions, no anesthesia required.
Minimal Downtime
Return to daily activities immediately.
Is the O-Shot right for everyone?
No single treatment is appropriate for every woman experiencing female sexual dysfunction.
Female sexual function can be influenced by multiple overlapping factors, including:
- Estrogen deficiency and menopause
- Testosterone and other hormonal factors
- Genitourinary syndrome of menopause (GSM)
- Vaginal dryness or atrophy
- Pelvic floor dysfunction
- Medications, including certain antidepressants
- Chronic medical conditions
- Pain disorders
- Stress, anxiety or depression
- Previous sexual experiences
- Relationship factors
Depending on the underlying cause, other treatments may be more appropriate than PRP or may be used as part of a broader treatment plan.
What to Expect After Treatment
Temporary effects following injection may include:
- Tenderness
- Swelling
- Bruising
- Spotting or minor bleeding
- Temporary discomfort at the injection site
As with any injection procedure, infection, bleeding and other complications are possible.
Most patients can return to normal daily activities shortly after treatment. Your provider will give you specific post-procedure instructions based on your treatment.
There is no guaranteed timeline for improvement, and individual responses vary.
Why Choose R2 Medical Clinic?
Female sexual dysfunction deserves the same comprehensive medical evaluation as any other health concern.
At R2 Medical Clinic, we do not assume that every sexual symptom has the same cause or requires the same treatment.
Your evaluation may include your medical and sexual health history, medications, menopausal status, hormonal factors, previous treatments and other potential contributors to your symptoms.
When PRP therapy is appropriate, it can be considered alongside other treatment options rather than as a one-size-fits-all solution.
Our goal is to identify potential contributors to your symptoms and develop an individualized treatment plan based on your health, symptoms and goals.
Frequently Asked Questions
Schedule Your Free Consultation
References & Medical Resources
- Clarke B, Gaddam N, Garcia B, et al. Vaginal Injection of Platelet-Rich Plasma for Sexual Function: A Randomized Controlled Trial. Obstetrics & Gynecology. 2026;147(5):627–635.
pubmed.ncbi.nlm.nih.gov - De Ponte A, Cabrera S, Bermúdez Sparice SS, Baulies S, Rodríguez I. Platelet-rich plasma in the management of vulvovaginal disorders: a systematic review. The Journal of Sexual Medicine. 2026;23(1):qdaf307.
pubmed.ncbi.nlm.nih.gov - Dankova I, Pyrgidis N, Tishukov M, et al. Efficacy and Safety of Platelet-Rich Plasma Injections for the Treatment of Female Sexual Dysfunction and Stress Urinary Incontinence: A Systematic Review. Biomedicines. 2023;11(11):2919.
mdpi.com - American College of Obstetricians and Gynecologists. Female Sexual Dysfunction. ACOG Practice Bulletin No. 213. Obstetrics & Gynecology. 2019.
acog.org
The information provided on this page is for educational purposes and is not intended to diagnose or treat any individual condition. Female sexual dysfunction may have multiple causes, and treatment recommendations should be based on an individualized medical evaluation. PRP for female sexual dysfunction remains an emerging treatment, results vary, and no specific outcome can be guaranteed.
Medically reviewed by Erik Natkin, DO — Founder, R2 Medical Clinic. Content last reviewed August 2026.